Consumer Information for: PENICILLIN G SODIUM FOR INJECTION, USP

Consumer Information

Information about the product including what the product is used for, dosage, warnings, proper use and side effects. This summary will not tell you everything about the product. Contact your healthcare professional if you have any questions about the product.


What the medication is used for
  • Penicillin G Sodium for Injection, USP is used to treat infections that are caused by certain types of bacteria.
  • Antibacterial drugs like Penicillin G Sodium for Injection, USP treat only bacterial infections. They do not treat viral infections.

What it does

Penicillin G Sodium for Injection, USP is an antibiotic that belongs to the penicillin class. It works by killing or stopping the growth of the bacteria that caused your infection.

When it should not be used

Do not use Penicillin G Sodium for Injection, USP if:

  • you are allergic to penicillin G sodium or other penicillin products.
What the medicinal ingredient is

penicillin G sodium

What dosage form it comes in

Penicillin G Sodium for Injection, USP is supplied as a dry powder in vials containing: 1 million, 5 million, or 10 million penicillin G units (as penicillin G sodium).

Warnings and precautions

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take Penicillin G Sodium for Injection, USP. Talk about any health conditions or problems you may have, including if you:

  • have had previous allergic reactions to other penicillins, cephalosporins, and other allergens.
  • have asthma.
  • have kidney disease.
  • have heart disease or vascular disease (issues with your veins or arteries).
  • are pregnant or planning to become pregnant.
  • are breastfeeding or planning to breastfeed.
Other warnings you should know about:
  • Your doctor may order certain tests or exams while you are taking Penicillin G Sodium for Injection, USP.
Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.
Interactions with this medication

The following may interact with Penicillin G Sodium for Injection, USP:

  • Antibiotics such as chloramphenicol, erythromycins, sulfonamides, and tetracyclines
  • Probenecid (to treat gout)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, phenylbutazone, and indomethacin
  • Diuretics such as thiazide diuretics, furosemide, and ethacrynic acid
Proper use of this medication

How to take Penicillin G Sodium for Injection, USP:

  • Although you may feel better early in treatment, Penicillin G Sodium for Injection, USP should be used exactly as directed.
  • Misuse or overuse of Penicillin G Sodium for Injection, USP could lead to the growth of bacteria that will not be killed by Penicillin G Sodium for Injection, USP (resistance). This means that Penicillin G Sodium for Injection, USP may not work for you in the future.
  • Do not share your medicine.
  • Your healthcare professional will prepare Penicillin G Sodium for Injection, USP before administering

Usual Dose

Adult dose:

  • Your healthcare professional will decide your dose based on your infection.

Infant and children dose:

  • Your healthcare professional will decide your child’s dose based on their weight and infection.

Overdose

If you think you have taken too much Penicillin G Sodium for Injection, USP, contact your healthcare professional, hospital emergency department or regional poison control centre immediately, even if there are no symptoms.

Side effects and what to do about them

These are not all the possible side effects you may feel when taking Penicillin G Sodium for Injection, USP. If you experience any side effects not listed here, contact your healthcare professional.

Serious side effects, how often they happen and what to do about them
Symptom / effect Talk with your doctor, nurse, or pharmacist only if severe Talk with your doctor, nurse, or pharmacist in all cases Stop taking drug and get immediate medical help
Jarisch–Herxheimer Reaction (Syphilis-Related Reaction): fever, headache, shaking chills, sweating, temporary worsening of sores, seizures, stroke, muscle pain, rapid heart rate, hyperventilation, flushing, and low blood pressure     ✘
Allergic Reaction: chills, fever, hives joint pain, rash, swelling, nausea, itching, muscle spasms, low blood pressure, vascular failure, difficulty breathing, discomfort, and abdominal pain     ✘
Neuropathy (Nervous System Damage): weakness, numbness, pain, overactive reflexes, muscle twitches, seizures, and coma ✘    
Congestive Heart Failure: chest discomfort with unpleasant awareness of your heartbeat, faintness, shortness of breath, and weakness     ✘
Nephropathy (Kidney Disease): back and abdominal pain, change in the colour of urine (pale or dark), decrease in amount of urine produced, pain or discomfort when urinating, swelling of the legs and ankles, and blood in the urine   ✘  
Pseudomembranous Colitis (Inflammation of the Colon): nausea, vomiting, inflammation of mouth or lips, black or hairy tongue, and gastrointestinal irritation   ✘  
Electrolyte Disturbances: weakness, drowsiness, muscle pain or cramps, and irregular heartbeat   ✘  
Phlebitis (Swelling of a Vein): pain, tenderness, and redness or swelling ✘    
Thrombophlebitis (Blood Clots): swelling and redness along a vein which is extremely tender or painful when touched ✘    

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.

How to store
  • Store dry powder at a controlled room temperature (between 15 °C and 25 °C).
  • Store reconstituted solution at a controlled room temperature (between 15 °C and 25 °C) for up to 24 hours or under refrigeration (between 2 °C and 8 °C) for up to 5 days.
  • Keep out of reach and sight of children.

Reporting side effects

Reporting Side Effects

You can report any suspected side effects associated with the use of health products to Health Canada by:

NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.

More information

If you want more information about Penicillin G Sodium for Injection, USP:

Fresenius Kabi Canada Ltd.
165 Galaxy Blvd, Suite 100
Toronto, ON M9W 0C8

Last revised: July 3, 2019

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